TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation
نویسندگان
چکیده
منابع مشابه
TRAF3 as a powerful and multitalented regulator of lymphocyte functions.
This review summarizes the current state of knowledge regarding the roles of the signaling adapter protein tumor necrosis factor receptor (TNFR)-associated factor 3 in regulating the functions of B and T lymphocytes. In B lymphocytes, TNFR-associated factor 3 inhibits signaling by TNFR superfamily receptors, Toll-like receptors, and interleukin-6R. In contrast, signaling to B cells by the viral...
متن کاملTRAF3 regulates B cell survival and IL-6 receptor signaling
has been approved by the Examining Committee for the thesis requirement for the Doctor of Philosophy degree in Immunology at the May 2015 graduation. ii To my family and friends, thank you for the endless support iii ACKNOWLEDGEMENTS First and foremost, I would like to thank my mentor, Dr. Gail Bishop, for her mentorship and support for the past five years. Gail provided me with excellent guida...
متن کاملB and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation
Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity.
The ShcA locus encodes 3 protein isoforms that differ in tissue specificity, subcellular localization, and function. Among these, p66Shc inhibits TCR coupling to the Ras/MAPK pathway and primes T cells to undergo apoptotic death. We have investigated the outcome of p66Shc deficiency on lymphocyte development and homeostasis. We show that p66Shc(-/-) mice develop an age-related lupus-like autoim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.02161